Med J Bakirkoy. 2020; 16(4): 385-391 | DOI: 10.5222/BMJ.2020.74946

Association Between Depression and Cardiometabolic Risk Factors in Adolescents with Obesity§

Asli Okbay Güneþ¹, Rahime Hülya Bingöl Çaðlayan², Ezgi Þen Demirdöðen², Selmin Kose³, Ethem Erginoz⁴, Oya Ercan⁵, Müjgan Alikaþifoðlu^6
1Department Of Pediatrics, Istanbul University- Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey
²Department Of Child and Adolescent Psychiatry, Istanbul University- Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey
³Departmant of Midwifery, Istanbul Bilim University, Istanbul, Turkey
⁴Department of Public Health, Istanbul University- Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey
⁵Department of Pediatrics Division of Adolescent Medicine and Endocrinology, Istanbul University- Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey
⁶Department of Pediatrics, Division of Adolescent Medicine, Istanbul University- Cerrahpasa, Cerrahpasa Medical Faculty,Istanbul, Turkey

Objective: The aim of this study was to examine whether the presence of depression in adolescents who were overweight or obese increase the likelihood of cardiometabolic risk factors.
Method: We performed a retrospective cross-sectional analysis of the data from adolescents who were overweight or obese, aged 11-18 years, who were evaluated in our clinic from January 2012 to December 2015. Depression was evaluated by “Children’s Depression Inventory”. Hypertension, dyslipidemia, hyperinsulinemia, hyperglycaemia and insulin resistance were defined as cardiometabolic risk factors. The degree of obesity was calculated as the body mass index standard deviation score.
Results: Among 283 adolescents 75 (26.5%) were overweight, and 208 (73.5%) had obesity, the mean age was 14.02±1.67 years and 168 (59.4%) of the subjects were girls. The body mass index standard deviation score was in median 2.36±0.62, Children’s Depression Inventory score was in median 12.72±6.5, and 47 (16.6%) of the participants were found depressed. Depression frequency was found higher in females than in males (p=0.047). Body mass index standard deviation score had positive correlation with Children’s Depression Inventory scores (r=0.123, p= 0.038). In univariate analysis, in depressed group hyperinsulinemia was found 2.3 times more frequent than in nondepressed group (p=0.026). In logistic regression analysis this relation disappeared.
Conclusion: We showed that severity of depression increased, as the degree of obesity increased, but we could not find any clear relationship between depression and cardiometabolic risk factors in adolescents who were overweight or obese.

Keywords: Adolescents, cardiometabolic risk factors, degree of obesity, depression

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Aþýrý Aðýrlýklý ve Þiþman Ergenlerde Depresyon ve Kardiyometabolik Risk Etmenlerinin Ýliþkisi

Asli Okbay Güneþ¹, Rahime Hülya Bingöl Çaðlayan², Ezgi Þen Demirdöðen², Selmin Kose³, Ethem Erginoz⁴, Oya Ercan⁵, Müjgan Alikaþifoðlu^6
1Istanbul Üniversitesi- Cerrahpaþa, Cerrahpaþa Týp Fakültesi, Pediatri Ana Bilim Dalý, Ýstanbul, Türkiye
²Ýstanbul Üniversitesi- Cerrahpaþa, Cerrahpaþa Týp Fakültesi, Çocuk ve Ergen Ruh Saðlýðý Hastalýklarý Ana Bilim Dalý,Ýstanbul, Türkiye
³Ýstanbul Bilim Üniversitesi, Ebelik Bilim Dalý, Ýstanbul, Türkiye
⁴Istanbul Üniversitesi- Cerrahpaþa, Cerrahpaþa Týp Fakültesi, Halk Saðlýðý Ana Bilim Dalý, Ýstanbul, Türkiye
⁵Istanbul Üniversitesi- Cerrahpaþa, Cerrahpaþa Týp Fakültesi, Pediatri Ana Bilim Dalý, Adolesan ve Endokrinoloji Bilim Dalý, Ýstanbul, Türkiye
⁶Istanbul Üniversitesi- Cerrahpaþa, Cerrahpaþa Týp Fakültesi, Pediatri Ana Bilim Dalý, Adolesan Bilim Dalý Ýstanbul, Türkiye

Amaç: Bu çalýþmanýn amacý aþýrý aðýrlýklý ya da þiþman ergenlerde depresyon varlýðýnýn kardiyometabolik risk etmenlerini artýrýp artýrmadýðýný incelemektir.
Yöntem: Ocak 2012 - Aralýk 2015 tarihleri arasýnda kliniðimizde deðerlendirilen, 11-18 yaþ arasý aþýrý aðýrlýklý ya da þiþman ergenlerin verilerinin geriye dönük kesitsel çözümlemesi yapýldý. Depresyon, “Çocuklar için Depresyon Ölçeði” ile deðerlendirildi. Hipertansiyon, dislipidemi, hiperinsülinemi, hiperglisemi ve insülin direnci kardiyometabolik risk etmenleri olarak tanýmlandý. Obezite derecesi, beden kitle indeksi standart sapma skoru olarak hesaplandý.
Bulgular: Çalýþmaya alýnan 283 ergenden 75'i (% 26.5) aþýrý aðýrlýklý, 208'i (% 73.5) þiþmandý. Olgularýn yaþ ortalamasý 14.02 ± 1.67 yýldý ve 168'i (% 59.4) kýzdý. Beden kitle indeksi standart sapma skoru ortanca deðeri 2.36 ± 0.62, Çocuklar için Depresyon Ölçeði ortanca puaný 12.72 ± 6.5 idi ve katýlýmcýlarýn 47'sinde (% 16.6) depresyon saptandý. Depresyon sýklýðý kýzlarda erkeklerden daha yüksek saptandý (p = 0.047). Beden kitle indeksi standart sapma skoru ile Çocuklar için Depresyon Ölçeði puanlarý arasýnda ayný yönlü anlamlý iliþki saptandý (r=0.123, p = 0.038). Tek deðiþkenli çözümlemelerde depresyonu olanlarda hiperinsülinemi, depresyonu olmayanlara gören 2.3 kat daha sýk bulundu (p = 0.026). Lojistik regresyon çözümlemesinde bu iliþki kayboldu.
Sonuç: Þiþmanlýðýn derecesi arttýkça depresyonun þiddetinin arttýðýný gösterdik, ancak aþýrý aðýrlýklý ya da þiþman ergenlerde depresyon ve kardiyometabolik risk etmenleri arasýnda bir iliþki bulamadýk.

Anahtar Kelimeler: Ergenler, kardiyometabolik risk etmenleri, þiþmanlýðýn derecesi, depresyon

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