Med J Bakirkoy. 2021; 17(1): 25-29 | DOI: 10.5222/BMJ.2021.81905

Effectiveness of lactate dehydrogenase to albumin ratio in diagnosis of pulmonary thromboembolism,

Recep ALANLI, Murat Bülent KÜÇÜKAY, Kadir Serkan YALÇIN
Department Of Internal Medicine, Faculty Of Medicine, Lokman Hekim University, Ankara, Turkey

Background: The aim of the study is to inspect effectiveness of lactate dehydrogenase (LDH) to albumin ratio (LAR) in patients with pulmonary thromboembolism (PTE).
Methods: In this single center and retrospective study, 307 patients who admitted to emergency unit, between January 2017 and March 2020, with chest pain and sudden developing dyspnea were enrolled. Computed tomography pulmonary angiogram (CTPA) were performed to confirm pulmonary embolism.
Results: LAR, neutrophil, monocyte, d-dimer, LDH values were significantly higher and albumin values were significantly lower in patients with pulmonary embolism compared to patients without pulmonary embolism. Average age of 307 participants were 68.93; 140 patients were confirmed for PTE and 167 were normal. Linear regression analysis for LAR in diagnosis of PTE, revealed a correlation coefficient as r=0.320 (p<0.001). Positive and negative predictive values for LAR in diagnosisi of PTE were, 63.3% and 75.2%, respectively. In ROC analysis relation of LAR to PTE was found to be stronger than LDH and albumin tests alone.
Conclusion: LAR, which is a very simple and available test, may be used as a novel parameter in diagnosis of PTE.

Keywords: albumin, lactate dehydrogenase, lactate dehydrogenase to albumin ratio, pulmonary thromboembolism

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Laktat dehidrojenaz albumin oranýnýn pulmoner emboli tanýsýnda etkinliði

Recep ALANLI, Murat Bülent KÜÇÜKAY, Kadir Serkan YALÇIN
Lokman Hekim Üniversitesi Týp Fakültesi Ýç Hastalýklarý Anabilim Dalý, Ankara

Amaç: Bu çalýþmanýn amacý laktat dehidrojenaz albumin oranýnýn (LAR) pulmoner tromboemboli (PTE) tanýsýndaki etkinliðini incelemektir.
Yöntem: Bu tek merkezli, retrospektif çalýþmada, Ocak 2017 ile Mart 2020 tarihleri arasýnda acil servise göðüs aðrýsý ve ani geliþen dispne nedeniyle baþvuran ve PTE þüphesi ile PBTA yapýlmýþ olan 307 hasta incelendi.
Bulgular: PTE saptanan hastalarda, PTE saptanmayan hastalarla kýyaslandýðýnda; LAR, nötrofil ve monosit sayýmlarý, d-dimer ve LDH deðerleri anlamlý olarak yüksek bulunurken, albumin deðerleri anlamlý olarak daha düþük bulundu. Katýlýmcýlarýn ortalama yaþý 68,93 olarak bulundu; 140 hastada PTE saptanýrken 167'sinde PTE saptanmadý. LAR ile PTE arasýndaki lineer regresyon analizinde korrelasyon katsayýsý r=0,320. LAR için pozitif prediktif deðer %63,3, negatif prediktif deðer %75,2 olarak bulundu. Receiver operator characteristics (ROC) eðrisi incelemesinde LAR ile PTE arasýndaki iliþki, tek baþýna LDH veya albumin testlerinden daha güçlü bulunmuþtur.
Sonuç: Basit ve her yerde yapýlabilir bir test olarak LAR, PTE tanýsýnda yeni bir parametre olarak kullanýlabilir.

Anahtar Kelimeler: albumin, laktat dehidrojenaz, laktat dehidrojenaz albumin oraný, pulmoner tromboembolizm

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