ISSN: 1305-9327

 
 

VOLUME: 14 NUMBER: 1
 
 

Login | Register | Forgot Your Password?|



Online article submission system has been turned over to ScopeMed. We kindly request you to submit your current article or new articles via ScopeMed system
COPYRIGHT TRANSFERM FORM
AUTHOR FORM
ICMJE FORM
INFORMATION for AUTHORS
Print version of Medical Journal of Bakirkoy has been stopped as of 2018; the journal continues to be published as e-journal starting with March 2018 issue.

RSS Feed
 
 
13 - Periampullary regional tumors, pylorus preserving whipple procedure and more than 10-year survival
   
Kemal Tekesin, Mehmet Emin Gunes
   
  ABSTRACT
   
  Introduction: This study analyzed factors affecting postoperative survival in patients with periampullary region tumors who underwent Whipple procedure and assessed survival of such patients more than 10 years.

Method: Patients with periampullary pancreatic tumors who underwent Whipple procedure in the last 3 years were retrospectively analyzed. Survival rates were statistically analyzed using the Kaplan-Meier method, and compared by the log-rank test. Multivariate survival was analyzed using a Cox proportional hazards model.

Results: Twenty-eight patients, 20 men and 8 women underwent surgery for periampullary tumor. There was no early mortality. Two patients had major and five had minor complications. One patient had chronic pancreatitis, one had duodenal gastrointestinal stromal tumor, and another had pancreatic neuroendocrine tumor while 25 of the patients had pancreatic, ampullary or choledochal adenocarcinoma. Postoperative survival was significantly longer in patients with ampullary than pancreatic cancer (p<0.001). Median survival rates of patients with stages I–IV tumors were 69.75, 33.80, 21.90 and 6.00 months, respectively (p<0.001). Overall survival was significantly longer in patients who received R0 resection (p<0.001) and in patients with node negative tumors (p=0.003). Survival rate was 13 folds lower in patients with portal vein resection (p=0.022).

Conclusion: Despite improvements in diagnosis, surgery and adjuvant treatments, patients with periampullary tumors have a very low survival rate≥10 years, if they are histopathologically diagnosed with adenocarcinoma. Early diagnosis, extended resection and optimal adjuvant treatment are needed to extend patient survival.
   
  Keywords
  Periampullary tumors, ampullary tumors, duodenum tumors, choledochal tumors, whipple procedure
   
  To download fulltext click here