ISSN: 1305-9327

 
 

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5 - Extremity soft tissue sarcomas of uncertain differentiation: presentation, treatment and outcomes in a clinical series of 60 patients
   
Recep Ozturk, Murat Aydin, Sefik Murat Arikan, Mehmet Akif Simsek, Ethem Toptas, Bedii Safak Gungor
   
  ABSTRACT
   
  Objectives: The purpose of this study is to assess the clinical characteristics and treatment modalities of 60 patients diagnosed with extremity soft tissue sarcomas of uncertain differentiation.

Methods: Clinical findings, treatments, outcomes and treatment failures in a case series of 59 patients, who were diagnosed with localized or metastatic extremity soft tissue sarcomas of uncertain differentiation between 2002 and 2015, were examined retrospectively.

Results: Out of 59 cases, 40 had synovial sarcoma, 7 had ASPS, 6 had extra-skeletal Ewing’s sarcoma, 3 had clear cell sarcoma, 2 had epithelioid sarcoma and 1 had extra-skeletal myxoid chondrosarcoma. Metastases were developed in 18 patients, whereas 42 patients had localized tumors at diagnosis. While 5-year overall survival rate was 36% in all patients, it was 46% in patients with localized tumor and 18% in patients who had metastasis at diagnosis. 23 patients died in 40.7 months on average (12-130). The mean diameter of the mass in all patients was 108±87 mm. The mean follow-up duration was 49.4±41.5 months (12-176).

Conclusions: Uncertainly differentiated soft tissue sarcomas are a group of diseases that are similar to benign tumors and some are very rare and have a very poor long-term prognosis. Wide surgical margin and early diagnosis are especially important.
   
  Keywords
  Sarcoma of uncertain differentiation, synovial sarcoma of the extremities, soft tissue sarcoma of the extremities, treatment outcome, prognosis
   
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